ABSTRACT
The objective of this multicenter prospective study was to determine the clinical efficacy and toxicity of a polychemotherapeutic third generation regimen, VACOP-B, with or without radiotherapy as front-line therapy in aggressive localized non-Hodgkin's lymphoma. Ninety-three adult patients (47 males and 46 females, median age 45 years) with aggressive localized non-Hodgkin's lymphoma, 43 in stage I and 50 in stage II (non-bulky), were included in the study. Stage I patients received VACOP-B for 6 weeks plus involved field radiotherapy and stage II patients received 12 weeks VACOP-B plus involved field radiotherapy on residual masses. Eighty-six (92.5 percent) achieved complete remission and 4 (4.3 percent) partial remission. Three patients (3.2 percent) were primarily resistant. Ten-year probability of survival, progression-free survival and disease-free survival were 87.3, 79.9 and 83.9 percent, respectively. Eighty-four patients are surviving at a median observation time of 57 months (range: 6-126). Statistical analysis showed no difference between stages I and II in terms of response, ten-year probability of survival, progression-free survival or disease-free survival. Side effects and toxicity were negligible and were similar in the two patient groups. The results of this prospective study suggest that 6 weeks of VACOP-B treatment plus radiotherapy may be the therapy of choice in stage I aggressive non-Hodgkin's lymphoma. Twelve weeks of VACOP-B treatment with or without radiotherapy was shown to be effective and feasible for stage II. These observations need to be confirmed by a phase III study comparing first and third generation protocols in stage I-II aggressive non-Hodgkin's lymphoma.
Subject(s)
Humans , Male , Female , Adolescent , Adult , Middle Aged , Lymphoma, Non-Hodgkin , Italy , Neoplasm Staging , Prospective Studies , Radiotherapy, Adjuvant , Survival Analysis , Treatment OutcomeABSTRACT
Se realizaron infiltraciones anestésicas en el implante de neoformaciones vesicales,permitiendo la resección endoscópica con similar efectividad que con técnicas anestésicas de mayor envergadura. En un período de 20 meses se realizaron 15 procedimientos en pacientes con enfermedades crónicasa subyacentes con al riesgo quirúrgico. Esta población cumplió criterios de inclusión de acuerdo: con el tipo de implante, la cantidad (no mayor de 3), y la zona de resección (no mayor de 1 campo endoscópico), realizándose la infiltración con lidocaína al 2 por ciento a través de un cateter uretral adaptado para punción bajo control endoscópico, con resección posterior. Así, en doce procedimientos se produjo anestesia completa, por la buena tolerancia y la resección total, en tres casos se necesitó una segunda aplicación más una asociación analgésica; no se registraron complicaciones posoperatorias inmediatas o tiempo quirúrgico prolongado; cuatro pacientes refirieron distensión vesical en respuesta a la oxibutinina 5 mg. Este procedimiento se presenta como una alternativa en pacientes de alto riesgo quirúrgico que requieren un tratamiento inmediato; la facilidad y la seguridad de su técnica permite un acto quirúrgico que requieren un tratamiento inmediato; la facilidad y la seguridad de su técnica permite un acto quirúrgico que requieren un tratamiento inmediato; la facilidad y la seguridad de su técnica permite un acto quirúrgico sin complicaciones; además, se reduce el costo de la práctica por la adecuación de materiales de uso común
Subject(s)
Humans , Male , Middle Aged , Anesthesia, Local , Endoscopy , Urinary Bladder Neoplasms , Lidocaine/administration & dosageABSTRACT
La resección transuretral de próstata (R.T.U.P.) es una de las operaciones más frecuentes en la cirugía urológica. Habitualmente se realiza bajo anestesia de tipo espinal y en algunos casos general. La anestesia localestá descripta, pero no es habitualmente utilizada. En el período comprendido entre marzo de 1996 y junio de 1998 se practicaron 35 R.T.U.P.bajo anestesia local. Se infiltró con lidocaína al 2 por ciento diluida al 50 por ciento el sitio a resecar, utilizando un catéter uretral modificado, que se introdujo a través del cistoscopio. Posterioermnete se realizó la R.T.U.P. y fue necesario completar con neuroleptoanalgesia en trs procedimientos. Todas las prácticas fueron bien toleradas por los pacientes y la evolución satisfactoria
Subject(s)
Humans , Male , Middle Aged , Anesthesia, Local , Transurethral Resection of Prostate , Lidocaine/administration & dosageABSTRACT
Exercise is worth while for general health and well being; and is beneficial and safe for the young with IDDM as well. The patient must learn to adapt to insulin and/or diet, attending education and training program. The many examples of world-class athletes and participants in the Olympic Games with diabetes serve as impressive evidence that in spite of being dependent on insulin, they are able to participate successfully and without complications in physical activities and high-performance sports.
Subject(s)
Child , Diabetes Mellitus, Type 1/therapy , Exercise , Humans , Insulin/administration & dosageABSTRACT
The so called diabetic diet, with a high intake of protein and fat, grown up in order to gain a better glycemic control, can be responsible for long term impairment of macro-angiopathic complication. For this reason many paediatric diabetologists, according to recent Dietary Allowances, recommend to diabetic children and adolescents a diet with the following characteristics: A variable total energy intake based on energy need High content of starch, particularly rich in soluble fibres Protein content lower than usual intake Increased mono and polyunsaturated fats.